skip to main content

Explore Research Products in the NSF-PAR

  • Home
  • Search Results
  • Page 1 of 1

Search for: All records

Creators/Authors contains: "Drobizhev, Mikhail"

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

  1. ; ; ; ; ; ; ; ; ; ; et al ( , Science Advances)
    A far-red fluorescent protein-based indicator allowed the imaging of synaptic Zn 2+ in brain slices and awake mice. 
    more » « less
    Full Text Available 
  2. ; ; ; ( , Frontiers in Molecular Biosciences)
    null (Ed.)
    Full Text Available 
  3. ; ; ; ; ; ; ; ; ; ; et al ( , PLOS Biology)
    Dutzler, Raimund (Ed.)
    Potassium ion (K + ) plays a critical role as an essential electrolyte in all biological systems. Genetically-encoded fluorescent K + biosensors are promising tools to further improve our understanding of K + -dependent processes under normal and pathological conditions. Here, we report the crystal structure of a previously reported genetically-encoded fluorescent K + biosensor, GINKO1, in the K + -bound state. Using structure-guided optimization and directed evolution, we have engineered an improved K + biosensor, designated GINKO2, with higher sensitivity and specificity. We have demonstrated the utility of GINKO2 for in vivo detection and imaging of K + dynamics in multiple model organisms, including bacteria, plants, and mice. 
    more » « less
    Full Text Available